Signal Transduction Inhibitor Therapy for Lymphoma
نویسندگان
چکیده
منابع مشابه
Hodgkin's lymphoma and CD30 signal transduction.
Advances in molecular biology have shed light on the biological basis of Hodgkin's lymphoma (HL). Knowledge of the biological basis has enabled us to understand that most Hodgkin and Reed-Sternberg (H-RS) cells are derived from germinal center B-cells and constitutive nuclear factor kappaB (NF-kappaB) activation is a common molecular feature. Molecular mechanisms responsible for constitutive NF...
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CD22 is a B-cell specific membrane glyco-protein that mediates homotypic and heterotypic celladhesion; it also regulates B-cell receptor (BCR)-mediatedsignals. Monoclonal antibodies (mAb) directed at theligand binding domain of CD22 initiate CD22-mediatedsignal transduction and apoptosis in B-cell lymphomas(NHL). Amino acid analysis of the complimentary deter-mining ...
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Malignant gliomas are the leading cause of central-nervous-system-tumour-related death, and despite recent advances in surgery, radiotherapy, and chemotherapy, current treatment regimens have a modest survival benefit; the prognosis is even worse in children with brain stem malignant gliomas. Gliomas are divided into four clinical grades on the basis of their histology and prognosis. The most m...
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ژورنال
عنوان ژورنال: Hematology
سال: 2010
ISSN: 1520-4391,1520-4383
DOI: 10.1182/asheducation-2010.1.265